OVERVIEW

Nexus 3D is a next-generation 3D in vitro platform designed to recreate the structural and functional complexity of human tissues.

Unlike conventional models, Nexus 3D™ incorporates perfusable vascular networks, enabling realistic nutrient transport, drug diffusion, and cellular interactions.

CORE FEATURES

1. Perfusable Vascular Networks

• Enables physiologically relevant transport

• Mimics capillary-scale diffusion and flow

2. High-Density Tissue Engineering

• Supports large cell populations

• Recapitulates native tissue architecture

3. Tunable Biomaterials

• Customizable hydrogel systems

• Controlled stiffness, porosity, and degradation

4. Modular & Scalable

• Adaptable to different tissue types

• Compatible with multi-well and high-throughput systems

WHY VASCULARIZATION MATTERS

Traditional models fail because they lack transport and gradients.

Nexus 3D enables:

• Realistic drug penetration

• Oxygen and nutrient gradients

• Cell–cell and cell–matrix interactions

APPlications

DRUG DISCOVERY

• Evaluate drug efficacy in physiologically relevant systems

• Study drug penetration in vascularized tissues

• Optimize dosing and combination therapies

DISEASE MODELING

• Cancer microenvironment modeling

• Fibrotic tissue development

• Human tissue models

PRECISION MEDICINE

• Patient-specific tissue constructs

• Personalized therapy testing

• Predictive response modeling

MECHANOBIOLOGY & FUNDAMENTAL RESEARCH

• Study cell–matrix interactions

• Investigate tissue remodeling

• Explore disease progression mechanisms