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UNMET NEED
Cell culture is traditionally performed in two-dimensional (2D) culture, a limited microenvironment that interferes with the natural cell behavior, phenotype, and drug responses. Unrealistic 2D conditions and some of the latest, non-vascularized 3D cultures translate into poor performance of preclinical models to predict drug efficacy in clinical trials. Thus, there is an unmet need to provide cell culture tools to create more representative models of human tissues.
TECHNOLOGY OVERVIEW
Nexus 3D™ allows the assembly of a 1 cm³ tissue embedded into a hydrogel with a capillary network allowing 3D vascularization. Tumor tissues in our Nexus 3D™ mimic and represent the way tumors behave in the body, leading to higher success rates and a shorter timeline for drug screening and lab testing.
HOW
As tumor cells cultured in Nexus 3D™ continue to grow, it is the best platform (along with built AI protocols for selecting optimal cell culture conditions and testing methods), for multi-drug testing and screening as part of prescribing more precise medicine to the patient.
1 single Nexus 3D™ can grow several hundred million cells with an excellent viability (70%), mimicking the size of human tumors
Drugs can rapidly diffuse into the Nexus 3D™, similar to a human tissue for pharmacological studies.
COMPETITIVE ADVANTAGES
Low production cost
Compatible with multiple hydrogels and cells
Improved models vs 3D spheroids vs 2D culture